SCHEMBL15280880

SCHEMBL15280880

CC(C)(C)C[C@H]1O[C@@H](n2cnc3c(=O)[nH]c(N)nc32)[C@@H](O)C1OC(C)(C)C

nearest known ligand 0.58

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ HINT1 P49773 6/20 0.58
▸ NT5E P21589 1/20 0.56
▸ GSK3A P49840 2/20 0.53
▸ RPS6KA3 P51812 2/20 0.53
▸ MAPK14 Q16539 2/20 0.53
▸ TGM2 P21980 1/20 0.52
▸ HPGD P15428 2/20 0.51
▸ PNP P00491 1/20 0.51
▸ FUT5 Q11128 1/20 0.51
▸ KRAS P01116 2/20 0.49
▸ STING1 Q86WV6 2/20 0.49
▸ PDE3B Q13370 1/20 0.49
▸ PDE3A Q14432 1/20 0.49
▸ TAAR1 Q96RJ0 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22292278 1.00 HINT1 (0.58) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL19887059 1.00 HINT1 (0.58) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL25070741 0.92 HINT1 (0.59) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL19887016 0.89 HINT1 (0.49) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL15280911 0.89 HINT1 (0.49) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL19522886 0.89 HINT1 (0.49) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL22292281 0.87 NT5E (0.57) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL22292279 0.87 NT5E (0.55) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL15280835 0.87 NT5E (0.57) HINT1NT5EGSK3ARPS6KA3MAPK14
SCHEMBL15280893 0.87 NT5E (0.55) HINT1NT5EGSK3ARPS6KA3MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240018516-A1 Agent for Regulating Expression and/or Function of RPS25 Gene Sumitomo Pharma Co., Ltd. (JP) 2024-01-18 — — US disclosed
US-9803199-B2 Cationic lipid DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-10-31 — — US disclosed
US-20160257951-A1 NOVEL LIPID DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-09-08 — — US disclosed
US-8987226-B2 Modified single-stranded polynucleotides DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-03-24 — — US disclosed
US-20130253038-A1 Modified Single-Stranded Polynucleotide DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-09-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160257951-A1 NOVEL LIPID NPC1L1, CETP, LIPC HINT1 2496/4885NT5E 963/4885GSK3A 4768/4885
US-20240018516-A1 Agent for Regulating Expression and/or Function of RPS25 Gene RPS25, RPS26, RPS24 HINT1 692/4885NT5E 1898/4885GSK3A 3860/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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