Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 8/20 | 0.78 |
| ▸ | SMO | Q99835 | 2/20 | 0.58 |
| ▸ | GRM1 | Q13255 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3579397 | 0.92 | SLC6A7 (0.65) | SLC6A7SMOGRM1ALDH1A1MAPK1 | |
| SCHEMBL3589980 | 0.88 | SLC6A7 (1.00) | SLC6A7SMOGRM1ALDH1A1 | |
| SCHEMBL3589975 | 0.88 | SLC6A7 (1.00) | SLC6A7SMOGRM1ALDH1A1 | |
| SCHEMBL3579880 | 0.85 | HSD11B1 (0.67) | SLC6A7SMOGRM1ALDH1A1MAPK1 | |
| SCHEMBL3578676 | 0.81 | SLC6A7 (0.83) | SLC6A7SMOGRM1ALDH1A1 | |
| SCHEMBL3579131 | 0.80 | SLC6A7 (0.83) | SLC6A7ALDH1A1MAPK1L3MBTL1KDM4E | |
| SCHEMBL27702484 | 0.80 | GRM1 (0.71) | SMOGRM1ALDH1A1DRD4HSD11B1 | |
| SCHEMBL12100509 | 0.79 | GRM1 (0.70) | SLC6A7SMOGRM1ALDH1A1MAPK1 | |
| SCHEMBL6352572 | 0.77 | DRD4 (0.72) | SLC6A7GRM1DRD4DRD2 | |
| SCHEMBL3581890 | 0.75 | HSD11B1 (0.62) | SLC6A7GRM1ALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893212-B1 | MULTICYCLIC COMPOUNDS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2013-10-16 | — | — | EP | disclosed |