Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PRF1 | P14222 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13836188 | 0.81 | MAPT (0.52) | ALDH1A1TSHRTNKSMAPTKDM4E | |
| SCHEMBL15603247 | 0.79 | MAPT (0.40) | ALDH1A1TSHRTNKSMAPTKDM4E | |
| SCHEMBL13835968 | 0.75 | TNKS (0.38) | ALDH1A1TSHRTNKSMAPTKDM4E | |
| SCHEMBL2337593 | 0.74 | KDM4E (0.48) | ALDH1A1TSHRMAPTKDM4ETDP1 | |
| SCHEMBL2003093 | 0.69 | MAPT (0.55) | ALDH1A1TSHRMAPTKDM4ETDP1 | |
| SCHEMBL10624618 | 0.68 | ALDH1A1 (0.52) | ALDH1A1TSHRTNKSMAPTKDM4E | |
| SCHEMBL11553562 | 0.68 | ALDH1A1 (0.62) | ALDH1A1TSHRTNKSMAPTKDM4E | |
| SCHEMBL2332179 | 0.67 | ALDH1A1 (0.44) | ALDH1A1TSHRTNKSMAPTKDM4E | |
| SCHEMBL2332646 | 0.65 | ACP1 (0.53) | ALDH1A1TSHRTNKSMAPTKDM4E | |
| SCHEMBL28429289 | 0.65 | KDM4E (0.54) | ALDH1A1TSHRMAPTKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140163092-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | N30 PHARMACEUTICALS, INC. (US) | 2014-06-12 | — | — | US | disclosed |
| US-8669381-B2 | Chromone inhibitors of S-nitrosoglutathione reductase | N30 PHARMACEUTICALS, INC. (US) | 2014-03-11 | — | — | US | disclosed |
| US-20130274320-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | NIVALIS THERAPEUTICS, INC. | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274320-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | POR, GSR, CBR1 | ALDH1A1 363/4885TSHR 887/4885TNKS 3959/4885 |
| US-20140163092-A1 | Chromone Inhibitors of S-Nitrosoglutathione Reductase | POR, GSR, CBR1 | ALDH1A1 363/4885TSHR 887/4885TNKS 3959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.