Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 1.00 |
| ▸ | GSK3A | P49840 | 7/20 | 1.00 |
| ▸ | PIM1 | P11309 | 9/20 | 0.67 |
| ▸ | CDK2 | P24941 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.59 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10118546 | 1.00 | GSK3B (1.00) | GSK3BGSK3APIM1CDK2MEN1 | |
| SCHEMBL14277836 | 0.88 | GSK3A (0.79) | GSK3BGSK3APIM1MEN1BLM | |
| SCHEMBL623748 | 0.87 | GSK3A (0.77) | GSK3BGSK3APIM1 | |
| SCHEMBL623749 | 0.87 | GSK3A (0.77) | GSK3BGSK3APIM1 | |
| SCHEMBL623750 | 0.87 | GSK3A (0.77) | GSK3BGSK3APIM1 | |
| SCHEMBL15315396 | 0.86 | GSK3B (0.76) | GSK3BGSK3ACDK2MEN1POLB | |
| SCHEMBL622714 | 0.86 | GSK3B (0.76) | GSK3BGSK3ACDK2MEN1POLB | |
| SCHEMBL623348 | 0.86 | GSK3B (0.76) | GSK3BGSK3ACDK2MEN1POLB | |
| SCHEMBL622715 | 0.86 | GSK3B (0.76) | GSK3BGSK3ACDK2MEN1POLB | |
| SCHEMBL623103 | 0.85 | CDK2 (0.76) | GSK3BGSK3ACDK2MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255088-B2 | Premature-termination-codons readthrough compounds | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-02-09 | — | — | US | disclosed |
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274283-A1 | PREMATURE-TERMINATION-CODONS READTHROUGH COMPOUNDS | UPF1, NUDT21, RNGTT | GSK3B 4721/4885GSK3A 4773/4885PIM1 3392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.