Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 1.00 |
| ▸ | CTSV | O60911 | 2/20 | 0.66 |
| ▸ | CTSL | P07711 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MYC | P01106 | 1/20 | 0.58 |
| ▸ | MAX | P61244 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.57 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.57 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.57 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3694733 | 0.87 | MAPT (0.77) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL6625749 | 0.85 | MAPT (0.73) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL8578400 | 0.84 | MAPT (0.73) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL6160631 | 0.84 | MAPT (0.72) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL3279807 | 0.84 | MAPT (0.72) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL11870435 | 0.83 | MAPT (0.71) | MAPTCTSVCTSLKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL15054415 | 0.83 | MAPT (0.71) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL4211532 | 0.83 | KMT2A (0.72) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL17434401 | 0.83 | MAPT (0.70) | MAPTCTSVCTSLKMT2AMEN1 | |
| SCHEMBL12825213 | 0.82 | MAPT (0.69) | MAPTCTSVCTSLKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117186082-A | 3- (2H-benzopyran-3-yl) -5-phenyl-1, 2, 4-oxadiazole derivative and preparation method and application thereof | 中国人民解放军军事科学院军事医学研究院 | 2023-12-08 | — | — | CN | disclosed |
| WO-2023083365-A1 | PAD4 INHIBITORS AND USE THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2023-05-19 | — | — | WO | disclosed |
| US-20210120813-A1 | INHIBITORS OF THE SHIKIMATE PATHWAY | ADAMA AGAN LTD. (IL) | 2021-04-29 | — | — | US | disclosed |
| US-20210120813-A1 | INHIBITORS OF THE SHIKIMATE PATHWAY | ADAMA AGAN LTD. (IL) | 2021-04-29 | — | — | US | disclosed |
| CN-103097359-B | Compounds as microsomal prostaglandin E2 synthase-1 inhibitors | 贝林格尔.英格海姆国际有限公司 | 2016-08-17 | — | — | CN | disclosed |
| US-8618115-B2 | Substituted thieno[3,2-d]pyrimidinones as MCHR1 antagonists and methods for using them | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-12-31 | — | — | US | disclosed |
| EP-1948665-B1 | THIENOPYRIMIDINONE DERIVATIVES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | BRISTOL MYERS SQUIBB CO (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2298776-A1 | Thienopyrimidinone derivatives as melanin concentrating hormone receptor-1 antagonists | Bristol-Myers Squibb Company (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-1948665-A2 | THIENOPYRIMIDINONE DERIVATIVES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007050726-A2 | THIENOPYRIMIDINONE DERIVATIVES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-05-03 | — | — | WO | disclosed |
| US-20070093509-A1 | Non-basic melanin concentrating hormone receptor-1 antagonists | BRISTOL-MYERS SQUIBB COMPANY | 2007-04-26 | — | — | US | disclosed |
| CN-1147248-A | N- (3-pyrrolidinyl) benzamide derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1997-04-09 | — | — | CN | disclosed |
| EP-0170069-B1 | HAIR-DYEING COMPOSITIONS | Henkel Kommanditgesellschaft auf Aktien (DE) | 1989-10-11 | — | — | EP | disclosed |
| US-4619666-A | Hair dyes containing amino-nitrobenzoic acid or amino-nitrobenzene sulfonic acids as substantive dyes | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1986-10-28 | — | — | US | disclosed |
| EP-0170069-A1 | Hair-dyeing compositions | Henkel Kommanditgesellschaft auf Aktien (DE) | 1986-02-05 | — | — | EP | disclosed |
| US-4089078-A | Arylazopyrazolone dyes for polyester | AMERICAN COLOR & CHEMICAL CORPORATION (US) | 1978-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210120813-A1 | INHIBITORS OF THE SHIKIMATE PATHWAY | KMO, PIKFYVE, DDT | MAPT 4000/4885CTSV 2705/4885CTSL 3628/4885 |
| US-20070093509-A1 | Non-basic melanin concentrating hormone receptor-1 antagonists | MCHR1, MCHR2, MC1R | MAPT 1990/4885CTSV 4250/4885CTSL 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.