Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | GRM6 | O15303 | 1/20 | 0.30 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313276 | 0.81 | MEN1 (0.40) | PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9108371 | 0.78 | — | — | |
| SCHEMBL15313220 | 0.76 | NPC1 (0.48) | VCAM1MAPK1TSHRMEN1KMT2A | |
| SCHEMBL9105334 | 0.71 | CHEK1 (0.39) | — | |
| SCHEMBL4943018 | 0.71 | CHEK1 (0.39) | — | |
| SCHEMBL9108861 | 0.68 | — | — | |
| SCHEMBL20856579 | 0.66 | MAPK1 (0.56) | VCAM1L3MBTL1MAPK1LMNATSHR | |
| SCHEMBL26629110 | 0.66 | MAPK1 (0.61) | VCAM1PKML3MBTL1MAPK1LMNA | |
| SCHEMBL23320472 | 0.65 | NPC1 (0.55) | LMNAMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL15312877 | 0.64 | MAPT (0.34) | PKMMAPK1LMNAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447080-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2016-09-20 | — | — | US | disclosed |
| US-9120775-B2 | Viral polymerase inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2015-09-01 | — | — | US | disclosed |
| US-20150065445-A1 | Viral Polymerase Inhibitors | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2015-03-05 | — | — | US | disclosed |
| US-20130274218-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-10-17 | — | — | US | disclosed |
| WO-2013152391-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2013-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065445-A1 | Viral Polymerase Inhibitors | POLR2E, POLM, POLR2H | VCAM1 2113/4885PKM 3102/4885L3MBTL1 3977/4885 |
| US-20130274218-A1 | VIRAL POLYMERASE INHIBITORS | POLR2E, POLM, POLR2H | VCAM1 2113/4885PKM 3102/4885L3MBTL1 3977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.