Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 6/20 | 0.68 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.68 |
| ▸ | BAD | Q92934 | 2/20 | 0.58 |
| ▸ | SRD5A2 | P31213 | 6/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9325719 | 0.93 | BCL2 (0.62) | BCL2MCL1BADSRD5A2PTPN1 | |
| SCHEMBL15313722 | 0.85 | BCL2 (0.78) | BCL2MCL1BADSRD5A2POLB | |
| SCHEMBL15313694 | 0.82 | LTA4H (0.52) | BCL2MCL1SRD5A2PTPN1PTPN2 | |
| SCHEMBL15313723 | 0.80 | MCL1 (0.71) | BCL2MCL1BADSRD5A2POLB | |
| SCHEMBL8430837 | 0.80 | BCL2 (0.59) | BCL2MCL1PTPN1PTPN2PTPN6 | |
| SCHEMBL5698161 | 0.79 | BCL2 (0.58) | BCL2MCL1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313721 | 0.78 | BCL2 (0.72) | BCL2MCL1BADSRD5A2POLB | |
| SCHEMBL13764672 | 0.78 | SRD5A2 (0.77) | SRD5A2POLB | |
| SCHEMBL28707306 | 0.78 | PTPN1 (0.73) | BCL2PTPN1PTPN2PTPN6 | |
| SCHEMBL9636703 | 0.77 | BCL2 (0.49) | BCL2MCL1SRD5A2PTPN1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |