Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 3/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | BAX | Q07812 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | IDH1 | O75874 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313715 | 0.92 | FFAR1 (0.46) | LTA4HSRD5A2BCL2BCL2L1MCL1 | |
| SCHEMBL15313716 | 0.90 | FFAR1 (0.44) | LTA4HSRD5A2BCL2BCL2L1MCL1 | |
| SCHEMBL15313709 | 0.87 | SRD5A2 (0.46) | LTA4HSRD5A2BCL2BCL2L1NR1H2 | |
| SCHEMBL15313712 | 0.87 | BCL2 (0.49) | LTA4HSRD5A2BCL2MCL1IDH1 | |
| SCHEMBL15313714 | 0.87 | RIPK1 (0.48) | LTA4HSRD5A2BCL2NR1H2BAX | |
| SCHEMBL15313713 | 0.84 | BCL2 (0.47) | LTA4HSRD5A2BCL2MCL1IDH1 | |
| SCHEMBL15313711 | 0.84 | BCL2 (0.59) | LTA4HSRD5A2BCL2MCL1IDH1 | |
| SCHEMBL8930618 | 0.83 | BCL2 (0.61) | BCL2BCL2L1PTPN1PTPN2PTPN6 | |
| SCHEMBL15313693 | 0.82 | BCL2 (0.68) | SRD5A2BCL2MCL1PTPN1PTPN2 | |
| SCHEMBL15313710 | 0.81 | LTA4H (0.50) | LTA4HSRD5A2NR1H2BAXIDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |