Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.62 |
| ▸ | BAD | Q92934 | 1/20 | 0.62 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.43 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313753 | 0.93 | BCL2 (0.65) | BCL2MCL1BADKMT2AAKR1C3 | |
| SCHEMBL15313742 | 0.93 | BCL2 (0.73) | BCL2MCL1BADDGAT1MGAT3 | |
| SCHEMBL15313755 | 0.90 | BCL2 (0.64) | BCL2MCL1BADDGAT1MGAT3 | |
| SCHEMBL15313763 | 0.88 | BCL2 (0.67) | BCL2MCL1BADDGAT1MGAT3 | |
| SCHEMBL15313754 | 0.88 | BCL2 (0.65) | BCL2MCL1BADDGAT1MGAT3 | |
| SCHEMBL15313757 | 0.88 | BCL2 (0.69) | BCL2MCL1BADKMT2AAKR1C3 | |
| SCHEMBL15314000 | 0.87 | BCL2 (0.47) | BCL2MCL1BADMEN1KMT2A | |
| SCHEMBL15313961 | 0.87 | BCL2 (0.65) | BCL2MCL1BADDGAT1MGAT3 | |
| SCHEMBL15313762 | 0.86 | BCL2 (0.59) | BCL2MCL1BADDGAT1MGAT3 | |
| SCHEMBL15313756 | 0.86 | BCL2 (0.65) | BCL2MCL1BADDGAT1MGAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |