Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | BAD | Q92934 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313742 | 0.89 | BCL2 (0.73) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313753 | 0.88 | BCL2 (0.65) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313754 | 0.88 | BCL2 (0.65) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313763 | 0.88 | BCL2 (0.67) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313961 | 0.86 | BCL2 (0.65) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313751 | 0.86 | BCL2 (0.63) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313756 | 0.86 | BCL2 (0.65) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313755 | 0.85 | BCL2 (0.64) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313757 | 0.85 | BCL2 (0.69) | BCL2MCL1BADALDH1A1LMNA | |
| SCHEMBL15313741 | 0.83 | BCL2 (0.61) | BCL2MCL1BADALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |