Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.63 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.52 |
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.52 |
| ▸ | CA9 | Q16790 | 3/20 | 0.52 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.51 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313831 | 0.88 | GPR27 (0.61) | P2RX1AVPR2GPR27GAAKMT2A | |
| SCHEMBL15313812 | 0.83 | BCL2L1 (0.68) | BCL2L1CA12CA1CA2CA9 | |
| SCHEMBL6930179 | 0.78 | P2RX1 (0.64) | P2RX1ALDH1A1LMNAGAAKMT2A | |
| SCHEMBL15313813 | 0.76 | TERT (0.58) | P2RX1PRMT1CA12CA1CA2 | |
| SCHEMBL18027773 | 0.74 | NPC1 (0.63) | LMNAPOLBKMT2AMEN1ALOX15 | |
| SCHEMBL18993422 | 0.74 | TERT (0.51) | P2RX1LMNAPOLBKMT2AMEN1 | |
| SCHEMBL9051568 | 0.74 | MEN1 (0.65) | ALDH1A1LMNAPOLBBCL2KMT2A | |
| SCHEMBL24460168 | 0.73 | ALDH1A1 (0.80) | P2RX1CA12CA1CA2CA9 | |
| SCHEMBL12189486 | 0.73 | GPR27 (0.59) | BCL2L1PRMT1AVPR2GPR27ALDH1A1 | |
| SCHEMBL2169619 | 0.72 | P2RX1 (1.00) | P2RX1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |