Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.51 |
| ▸ | BCL2 | P10415 | 3/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESRRB | O95718 | 1/20 | 0.38 |
| ▸ | ESRRG | P62508 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313789 | 0.93 | BCL2 (0.57) | BCL2L1BCL2PPARGNR1H4LMNA | |
| SCHEMBL15313805 | 0.85 | BCL2 (0.58) | BCL2L1BCL2PPARGNR1H4LMNA | |
| SCHEMBL15313783 | 0.81 | BCL2 (0.59) | BCL2L1BCL2LMNAPOLBALDH1A1 | |
| SCHEMBL15313787 | 0.78 | BCL2 (0.56) | BCL2L1BCL2PPARGNR1H4LMNA | |
| SCHEMBL15313809 | 0.78 | BCL2L1 (0.57) | BCL2L1BCL2LMNAPOLBALDH1A1 | |
| SCHEMBL15313811 | 0.77 | BCL2 (0.71) | BCL2L1BCL2LMNAPOLBALDH1A1 | |
| SCHEMBL15313822 | 0.76 | BCL2 (0.58) | BCL2L1BCL2LMNAPOLBMCL1 | |
| SCHEMBL15313804 | 0.74 | BCL2L1 (0.72) | BCL2L1BCL2NR1H4LMNAESRRG | |
| SCHEMBL15313817 | 0.74 | BCL2 (0.60) | BCL2L1BCL2LMNAPOLBMCL1 | |
| SCHEMBL15313797 | 0.74 | BCL2L1 (0.54) | BCL2L1BCL2NR1H4ESRRGMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |