Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.54 |
| ▸ | BCL2 | P10415 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | ESRRG | P62508 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 2/20 | 0.38 |
| ▸ | KLK1 | P06870 | 2/20 | 0.38 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313794 | 0.96 | BCL2L1 (0.56) | BCL2L1BCL2MCL1SIRT5ESRRG | |
| SCHEMBL15313806 | 0.92 | BCL2L1 (0.59) | BCL2L1BCL2MCL1SIRT5ESRRG | |
| SCHEMBL15313804 | 0.86 | BCL2L1 (0.72) | BCL2L1BCL2MCL1SIRT5ESRRG | |
| SCHEMBL15313802 | 0.82 | BCL2 (0.75) | BCL2L1BCL2MCL1SIRT5RORC | |
| SCHEMBL15313787 | 0.81 | BCL2 (0.56) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313807 | 0.78 | BCL2L1 (0.79) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313789 | 0.75 | BCL2 (0.57) | BCL2L1BCL2MCL1SIRT5ESRRG | |
| SCHEMBL15313825 | 0.74 | BCL2L1 (0.51) | BCL2L1BCL2MCL1SIRT5ESRRG | |
| SCHEMBL15313895 | 0.71 | BCL2L1 (0.84) | BCL2L1BCL2MCL1SIRT5NR1H4 | |
| SCHEMBL15313786 | 0.70 | BCL2 (0.67) | BCL2L1BCL2MCL1SIRT5CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |