Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313786 | 0.90 | BCL2 (0.67) | BCL2BCL2L1CA1CA2MCL1 | |
| SCHEMBL15313804 | 0.83 | BCL2L1 (0.72) | BCL2BCL2L1CA1CA2MCL1 | |
| SCHEMBL15313794 | 0.82 | BCL2L1 (0.56) | BCL2BCL2L1MCL1SIRT5NR1H4 | |
| SCHEMBL15313797 | 0.81 | BCL2L1 (0.54) | BCL2BCL2L1CA1CA2MCL1 | |
| SCHEMBL15313789 | 0.79 | BCL2 (0.57) | BCL2BCL2L1MCL1SIRT5NR1H4 | |
| SCHEMBL15313825 | 0.78 | BCL2L1 (0.51) | BCL2BCL2L1CA1CA2MCL1 | |
| SCHEMBL15313796 | 0.77 | BCL2 (0.54) | BCL2CA1CA2SMN1; SMN2ALDH1A1 | |
| SCHEMBL15313791 | 0.77 | LMNA (0.57) | NR1H4ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL15313849 | 0.75 | BCL2 (0.67) | BCL2BCL2L1CA1CA2MCL1 | |
| SCHEMBL15313807 | 0.75 | BCL2L1 (0.79) | BCL2BCL2L1CA1CA2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |