Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.83 |
| ▸ | BCL2 | P10415 | 4/20 | 0.75 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.75 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.75 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.39 |
| ▸ | KLK1 | P06870 | 2/20 | 0.39 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.39 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313860 | 0.91 | BCL2L1 (0.67) | BCL2L1BCL2MCL1SIRT5HTR6 | |
| SCHEMBL15313895 | 0.86 | BCL2L1 (0.84) | BCL2L1BCL2MCL1SIRT5LMNA | |
| SCHEMBL15313856 | 0.86 | BCL2L1 (0.77) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL687266 | 0.86 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5MAPT | |
| SCHEMBL29359532 | 0.86 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5MAPT | |
| SCHEMBL29360605 | 0.86 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5MAPT | |
| SCHEMBL15313864 | 0.85 | BCL2L1 (0.65) | BCL2L1BCL2MCL1SIRT5HTR6 | |
| SCHEMBL15313861 | 0.84 | BCL2 (0.63) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313807 | 0.84 | BCL2L1 (0.79) | BCL2L1BCL2MCL1SIRT5PLG | |
| SCHEMBL15313869 | 0.83 | BCL2L1 (0.61) | BCL2L1BCL2MCL1SIRT5HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |