Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.84 |
| ▸ | BCL2 | P10415 | 5/20 | 0.76 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.75 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.75 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313807 | 0.93 | BCL2L1 (0.79) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313856 | 0.90 | BCL2L1 (0.77) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313820 | 0.86 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5PRMT1 | |
| SCHEMBL15313843 | 0.86 | BCL2L1 (0.83) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL29360605 | 0.86 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL687266 | 0.86 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL29359532 | 0.86 | BCL2 (1.00) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313804 | 0.85 | BCL2L1 (0.72) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313808 | 0.83 | BCL2L1 (0.77) | BCL2L1BCL2MCL1SIRT5NAMPT | |
| SCHEMBL15313865 | 0.81 | BCL2L1 (0.67) | BCL2L1BCL2MCL1SIRT5PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |