Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.61 |
| ▸ | BCL2 | P10415 | 3/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313864 | 0.94 | BCL2L1 (0.65) | BCL2L1BCL2MCL1SIRT5HTR6 | |
| SCHEMBL15313865 | 0.90 | BCL2L1 (0.67) | BCL2L1BCL2MCL1SIRT5MAPT | |
| SCHEMBL15313854 | 0.89 | BCL2L1 (0.64) | BCL2L1BCL2MCL1SIRT5F10 | |
| SCHEMBL15313843 | 0.83 | BCL2L1 (0.83) | BCL2L1BCL2MCL1SIRT5HTR6 | |
| SCHEMBL15313868 | 0.81 | BCL2L1 (0.61) | BCL2L1BCL2MCL1SIRT5MAPT | |
| SCHEMBL15313863 | 0.81 | BCL2 (0.60) | BCL2L1BCL2MCL1SIRT5HTR6 | |
| SCHEMBL15313884 | 0.78 | BCL2L1 (0.59) | BCL2L1BCL2MCL1SIRT5MAPT | |
| SCHEMBL15313873 | 0.78 | BCL2L1 (0.58) | BCL2L1BCL2MCL1SIRT5CYP1A2 | |
| SCHEMBL15313877 | 0.76 | BCL2L1 (0.56) | BCL2L1BCL2MCL1SIRT5MAPT | |
| SCHEMBL15313856 | 0.76 | BCL2L1 (0.77) | BCL2L1BCL2MCL1SIRT5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |