Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313851 | 0.89 | BCL2 (0.56) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313842 | 0.88 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313852 | 0.85 | BCL2 (0.59) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313911 | 0.84 | BCL2 (0.53) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313845 | 0.80 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313846 | 0.80 | BCL2 (0.57) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313838 | 0.80 | BCL2 (0.66) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313844 | 0.80 | BCL2 (0.55) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313828 | 0.78 | BCL2 (0.55) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313801 | 0.77 | BCL2L1 (0.60) | BCL2BCL2L1MCL1SIRT5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |