Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 3/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | GPR27 | Q9NS67 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313845 | 0.92 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313852 | 0.90 | BCL2 (0.59) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313850 | 0.89 | BCL2 (0.56) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313801 | 0.82 | BCL2L1 (0.60) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313842 | 0.81 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313844 | 0.80 | BCL2 (0.55) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313827 | 0.78 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5HTT | |
| SCHEMBL15313841 | 0.78 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313828 | 0.76 | BCL2 (0.55) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313822 | 0.76 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |