Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313814 | 0.84 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL15313801 | 0.84 | BCL2L1 (0.60) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL15313816 | 0.83 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5LPAR1 | |
| SCHEMBL15313822 | 0.82 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL15554034 | 0.79 | BCL2 (0.77) | BCL2BCL2L1MCL1SIRT5CYP1A2 | |
| SCHEMBL15313852 | 0.79 | BCL2 (0.59) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL15313842 | 0.78 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5CYP2C19 | |
| SCHEMBL15313850 | 0.78 | BCL2 (0.56) | BCL2BCL2L1MCL1SIRT5ALDH1A1 | |
| SCHEMBL15005278 | 0.77 | BCL2 (0.51) | BCL2BCL2L1MCL1SIRT5LPAR1 | |
| SCHEMBL15313851 | 0.76 | BCL2 (0.56) | BCL2BCL2L1MCL1SIRT5TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |