Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.61 |
| ▸ | BCL2 | P10415 | 3/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313884 | 0.84 | BCL2L1 (0.59) | BCL2L1BCL2MCL1SIRT5MEN1 | |
| SCHEMBL15313864 | 0.83 | BCL2L1 (0.65) | BCL2L1BCL2MCL1SIRT5HDAC1 | |
| SCHEMBL15313854 | 0.83 | BCL2L1 (0.64) | BCL2L1BCL2MCL1SIRT5F10 | |
| SCHEMBL15313865 | 0.81 | BCL2L1 (0.67) | BCL2L1BCL2MCL1SIRT5F10 | |
| SCHEMBL15313869 | 0.81 | BCL2L1 (0.61) | BCL2L1BCL2MCL1SIRT5F10 | |
| SCHEMBL15313856 | 0.75 | BCL2L1 (0.77) | BCL2L1BCL2MCL1SIRT5HSD11B1 | |
| SCHEMBL15313843 | 0.75 | BCL2L1 (0.83) | BCL2L1BCL2MCL1SIRT5MEN1 | |
| SCHEMBL15313895 | 0.75 | BCL2L1 (0.84) | BCL2L1BCL2MCL1SIRT5HSD11B1 | |
| SCHEMBL15313873 | 0.73 | BCL2L1 (0.58) | BCL2L1BCL2MCL1SIRT5HSD11B1 | |
| SCHEMBL15313807 | 0.73 | BCL2L1 (0.79) | BCL2L1BCL2MCL1SIRT5HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |