Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.51 |
| ▸ | BCL2 | P10415 | 2/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.39 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313854 | 0.86 | BCL2L1 (0.64) | BCL2L1BCL2MCL1SIRT5ENPP1 | |
| SCHEMBL15313873 | 0.86 | BCL2L1 (0.58) | BCL2L1BCL2MCL1SIRT5ENPP1 | |
| SCHEMBL15313877 | 0.85 | BCL2L1 (0.56) | BCL2L1BCL2MCL1SIRT5ENPP1 | |
| SCHEMBL15313872 | 0.82 | BCL2 (0.50) | BCL2L1BCL2MCL1SIRT5ENPP1 | |
| SCHEMBL15313869 | 0.75 | BCL2L1 (0.61) | BCL2L1BCL2MCL1SIRT5DEGS1 | |
| SCHEMBL15313865 | 0.75 | BCL2L1 (0.67) | BCL2L1BCL2MCL1SIRT5PRMT1 | |
| SCHEMBL15313856 | 0.73 | BCL2L1 (0.77) | BCL2L1BCL2MCL1SIRT5ENPP1 | |
| SCHEMBL15313878 | 0.73 | BCL2L1 (0.58) | BCL2L1BCL2MCL1SIRT5ENPP1 | |
| SCHEMBL15313864 | 0.72 | BCL2L1 (0.65) | BCL2L1BCL2MCL1SIRT5DEGS1 | |
| SCHEMBL15313868 | 0.69 | BCL2L1 (0.61) | BCL2L1BCL2MCL1SIRT5ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |