Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.59 |
| ▸ | BCL2 | P10415 | 1/20 | 0.59 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313855 | 0.89 | BCL2L1 (0.61) | BCL2L1BCL2SLC16A1LMNAPOLB | |
| SCHEMBL15313848 | 0.83 | BCL2L1 (0.56) | BCL2L1BCL2TP53SLC16A1LMNA | |
| SCHEMBL15313811 | 0.76 | BCL2 (0.71) | BCL2L1BCL2SLC16A1LMNAPOLB | |
| SCHEMBL4304061 | 0.76 | BCL2L1 (0.77) | BCL2L1BCL2SLC16A1LMNAPOLB | |
| SCHEMBL29377616 | 0.76 | BCL2L1 (0.77) | BCL2L1BCL2SLC16A1LMNAPOLB | |
| SCHEMBL15313785 | 0.75 | BCL2 (0.67) | BCL2L1BCL2TP53SLC16A1LMNA | |
| SCHEMBL14163444 | 0.75 | BCL2L1 (1.00) | BCL2L1BCL2SLC16A1LMNAPOLB | |
| SCHEMBL14264656 | 0.75 | BCL2 (1.00) | BCL2L1BCL2SLC16A1LMNAPOLB | |
| SCHEMBL15313812 | 0.74 | BCL2L1 (0.68) | BCL2L1BCL2SLC16A1LMNAPOLB | |
| SCHEMBL15313783 | 0.74 | BCL2 (0.59) | BCL2L1BCL2TP53SLC16A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |