Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.63 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.63 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.63 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.63 |
| ▸ | MMP2 | P08253 | 12/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 7/20 | 0.40 |
| ▸ | MMP14 | P50281 | 4/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.40 |
| ▸ | MMP7 | P09237 | 2/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313897 | 1.00 | BCL2 (0.63) | BCL2BCL2L1MCL1SIRT5MMP2 | |
| SCHEMBL15313893 | 0.88 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5MMP2 | |
| SCHEMBL15313894 | 0.88 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5MMP2 | |
| SCHEMBL15313888 | 0.87 | BCL2 (0.59) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313842 | 0.83 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5 | |
| SCHEMBL15313904 | 0.82 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5MMP2 | |
| SCHEMBL15313902 | 0.81 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5MMP2 | |
| SCHEMBL15313827 | 0.80 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5 | |
| SCHEMBL15313841 | 0.80 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5 | |
| SCHEMBL15313814 | 0.80 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |