Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.61 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPN | P05981 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313888 | 0.89 | BCL2 (0.59) | BCL2BCL2L1MCL1SIRT5POLB | |
| SCHEMBL15313892 | 0.88 | BCL2 (0.63) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313897 | 0.88 | BCL2 (0.63) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313893 | 0.87 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5AVPR2 | |
| SCHEMBL15313904 | 0.84 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5MAPT | |
| SCHEMBL15313902 | 0.83 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5MAPT | |
| SCHEMBL15313841 | 0.82 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5AVPR2 | |
| SCHEMBL15313842 | 0.82 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5GPR27 | |
| SCHEMBL15313814 | 0.81 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5LMNA | |
| SCHEMBL15313827 | 0.79 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5AVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |