Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 5/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.59 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.59 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | BMP1 | P13497 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313904 | 0.94 | BCL2 (0.58) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313902 | 0.92 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313893 | 0.90 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313894 | 0.89 | BCL2 (0.61) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313892 | 0.87 | BCL2 (0.63) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313897 | 0.87 | BCL2 (0.63) | BCL2BCL2L1MCL1SIRT5MMP9 | |
| SCHEMBL15313891 | 0.83 | ALDH1A1 (0.49) | BCL2BCL2L1MCL1SIRT5GAA | |
| SCHEMBL15313842 | 0.80 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5CA12 | |
| SCHEMBL15313814 | 0.79 | BCL2 (0.68) | BCL2BCL2L1MCL1SIRT5GAA | |
| SCHEMBL15313838 | 0.78 | BCL2 (0.66) | BCL2BCL2L1MCL1SIRT5CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |