Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 4/20 | 1.00 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.61 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.56 |
| ▸ | PRMT1 | Q99873 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | DDIT3 | P35638 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313847 | 0.87 | BCL2 (1.00) | BCL2BCL2L1KMT2AMEN1HPGD | |
| SCHEMBL15313853 | 0.87 | BCL2 (0.77) | BCL2BCL2L1MCL1SIRT5PRMT1 | |
| SCHEMBL15313895 | 0.86 | BCL2L1 (0.84) | BCL2BCL2L1MCL1SIRT5PRMT1 | |
| SCHEMBL15313905 | 0.83 | BCL2 (0.70) | BCL2BCL2L1MCL1SIRT5PRMT1 | |
| SCHEMBL15313824 | 0.81 | BCL2 (0.68) | BCL2BCL2L1KMT2AMAPTNAMPT | |
| SCHEMBL15313785 | 0.81 | BCL2 (0.67) | BCL2BCL2L1MCL1SIRT5KMT2A | |
| SCHEMBL15313786 | 0.81 | BCL2 (0.67) | BCL2BCL2L1MCL1SIRT5PRMT1 | |
| SCHEMBL15313807 | 0.80 | BCL2L1 (0.79) | BCL2BCL2L1MCL1SIRT5KMT2A | |
| SCHEMBL15313838 | 0.80 | BCL2 (0.66) | BCL2BCL2L1MCL1SIRT5KMT2A | |
| SCHEMBL15313836 | 0.79 | BCL2 (0.64) | BCL2BCL2L1MCL1SIRT5KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |