Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.58 |
| ▸ | BCL2 | P10415 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15313737 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL15313736 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL15314343 | 0.86 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL15313764 | 0.84 | MEN1 (0.51) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL15314009 | 0.79 | BCL2 (0.54) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL4384771 | 0.79 | TP53 (0.59) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL15313748 | 0.78 | BCL2 (0.50) | ALDH1A1SMN1; SMN2MEN1KMT2ABCL2 | |
| SCHEMBL15313759 | 0.77 | BCL2 (0.55) | ALDH1A1SMN1; SMN2MEN1KMT2ABCL2 | |
| SCHEMBL15313758 | 0.77 | BCL2 (0.63) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL15313740 | 0.76 | BCL2 (0.53) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8557812-B2 | Small molecule inhibitors of anti-apoptotic BCL-2 family members and the uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2013-10-15 | — | — | US | disclosed |