Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.73 |
| ▸ | TP53 | P04637 | 5/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.73 |
| ▸ | GAA | P10253 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3431636 | 0.84 | ALDH1A1 (0.79) | KDM4EHSD17B10ALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL29412072 | 0.81 | TP53 (0.78) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL15567817 | 0.81 | TP53 (0.78) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL30424878 | 0.81 | KDM4E (0.72) | KDM4EHSD17B10RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL29411938 | 0.80 | TP53 (0.68) | KDM4ERECQLALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL2245507 | 0.80 | KDM4E (0.68) | KDM4EHSD17B10RECQLALDH1A1SMN1; SMN2 | |
| SCHEMBL28903093 | 0.80 | TP53 (0.68) | KDM4ERECQLALDH1A1SMN1; SMN2TP53 | |
| SCHEMBL15314762 | 0.80 | ALDH1A1 (0.73) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL29411911 | 0.80 | ALDH1A1 (0.73) | KDM4EHSD17B10RECQLALDH1A1TP53 | |
| SCHEMBL8266132 | 0.80 | TP53 (0.74) | KDM4EHSD17B10RECQLALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170095481-A1 | Compounds That Enhance ATOH1 Expression | BRIGHAM & WOMEN'S HOSPITAL, INC. | 2017-04-06 | — | — | US | disclosed |
| US-9433610-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2016-09-06 | — | — | US | disclosed |
| US-20150157607-A1 | Compounds that Enhance Atoh1 Expression | MASSACHUSETTS EYE & EAR INFIRMARY | 2015-06-11 | — | — | US | disclosed |
| US-8859597-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2014-10-14 | — | — | US | disclosed |
| EP-2732819-A2 | Compounds that enhance Atoh-1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2014-05-21 | — | — | EP | disclosed |
| EP-2254572-B1 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRM (US) | 2013-10-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170095481-A1 | Compounds That Enhance ATOH1 Expression | DACH1, EZH1, CREBBP | KDM4E 1336/4885HSD17B10 552/4885RECQL 2299/4885 |
| US-20150157607-A1 | Compounds that Enhance Atoh1 Expression | DACH1, EZH1, CREBBP | KDM4E 1336/4885HSD17B10 552/4885RECQL 2299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.