Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 12/20 | 0.68 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598820 | 0.89 | EGLN1 (0.70) | VEGFAEGLN1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL273125 | 0.89 | VEGFA (0.70) | VEGFAEGLN1SMN1; SMN2 | |
| SCHEMBL21667235 | 0.83 | VEGFA (0.79) | VEGFAEGLN1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL12598822 | 0.82 | VEGFA (0.84) | VEGFAEGLN1 | |
| SCHEMBL1772403 | 0.81 | VEGFA (1.00) | VEGFAEGLN1 | |
| SCHEMBL278429 | 0.81 | VEGFA (1.00) | VEGFAEGLN1 | |
| SCHEMBL14598757 | 0.81 | NPSR1 (0.55) | SMN1; SMN2CYP1A2CYP2C19KDM4ENPSR1 | |
| SCHEMBL9969600 | 0.81 | NPSR1 (0.55) | SMN1; SMN2CYP1A2CYP2C19KDM4ENPSR1 | |
| SCHEMBL12964221 | 0.81 | NPSR1 (0.55) | SMN1; SMN2CYP1A2CYP2C19KDM4ENPSR1 | |
| SCHEMBL12598821 | 0.80 | EGLN1 (1.00) | VEGFAEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2952192-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2649998-B1 | Prolyl hydroxylase inhibitors | AERPIO THERAPEUTICS INC (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2649998-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2013-10-16 | — | — | EP | disclosed |