Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 12/20 | 0.79 |
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.79 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598822 | 0.90 | VEGFA (0.84) | VEGFAEGLN1 | |
| SCHEMBL278429 | 0.88 | VEGFA (1.00) | VEGFAEGLN1DRD2DRD3 | |
| SCHEMBL1772403 | 0.88 | VEGFA (1.00) | VEGFAEGLN1DRD2DRD3 | |
| SCHEMBL12598821 | 0.88 | EGLN1 (1.00) | VEGFAEGLN1 | |
| SCHEMBL15314767 | 0.83 | VEGFA (0.68) | VEGFAEGLN1TP53KDM4ECYP2D6 | |
| SCHEMBL12598820 | 0.81 | EGLN1 (0.70) | VEGFAEGLN1SMN1; SMN2NPSR1 | |
| SCHEMBL273125 | 0.81 | VEGFA (0.70) | VEGFAEGLN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL17340686 | 0.80 | VEGFA (0.70) | VEGFAEGLN1TP53DRD2DRD3 | |
| SCHEMBL30274428 | 0.78 | EGLN1 (0.63) | VEGFAEGLN1LMNAKDM4EALDH1A1 | |
| SCHEMBL277774 | 0.78 | EGLN1 (0.63) | VEGFAEGLN1LMNAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3603644-A1 | PROLYL HYDROXYLASE INHIBITORS | Aerpio Therapeutics, Inc. (US) | 2020-02-05 | — | — | EP | disclosed |