SCHEMBL273125

SCHEMBL273125

COC(=O)C1CCCN1Cc1ccn(Cc2ccccc2)c(=O)c1O

nearest known ligand 0.70

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
VEGFA P15692 12/20 0.70
EGLN1 Q9GZT9 12/20 0.70
LTA4H P09960 2/20 0.49
FKBP1A P62942 1/20 0.48
ADRA1D P25100 1/20 0.44
ADRA1A P35348 1/20 0.44
ADRA1B P35368 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
ALDH1A1 P00352 1/20 0.44
IDO1 P14902 1/20 0.42
TDO2 P48775 1/20 0.42
PDCD1 Q15116 1/20 0.41
CD274 Q9NZQ7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15314767 0.89 VEGFA (0.68) VEGFAEGLN1SMN1; SMN2
SCHEMBL12598820 0.86 EGLN1 (0.70) VEGFAEGLN1SMN1; SMN2
SCHEMBL278429 0.82 VEGFA (1.00) VEGFAEGLN1
SCHEMBL1772403 0.82 VEGFA (1.00) VEGFAEGLN1
SCHEMBL952722 0.82 LTA4H (0.63) LTA4HFKBP1AADRA1DADRA1AADRA1B
SCHEMBL952721 0.82 LTA4H (0.63) LTA4HFKBP1AADRA1DADRA1AADRA1B
SCHEMBL19465330 0.82 LTA4H (0.63) LTA4HFKBP1AADRA1DADRA1AADRA1B
SCHEMBL21667235 0.81 VEGFA (0.79) VEGFAEGLN1SMN1; SMN2ALDH1A1
SCHEMBL12598822 0.80 VEGFA (0.84) VEGFAEGLN1
SCHEMBL7181767 0.79 MEN1 (0.60) LTA4HFKBP1ASMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2496082-B1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC (US) 2016-10-12 EP claimed
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2015-06-11 US claimed
US-8999971-B2 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha AERPIO THERAPEUTICS INC. (US) 2015-04-07 US claimed
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2014-12-11 US claimed
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS INC. (US) 2013-06-20 US claimed
EP-2496082-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA Aerpio Therapeutics Inc. (US) 2012-09-12 EP claimed
WO-2011057112-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AKEBIA THERAPEUTICS INC. (US) 2011-05-12 WO claimed
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA AERPIO THERAPEUTICS LLC 2011-05-12 US claimed
US-7247648-B2 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2007-07-24 US claimed
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-10-20 US claimed
CN-116018136-A Hypoxia-inducible factor prolyl hydroxylase inhibitors for the treatment of aging-related disorders 百爱及生物医药公司 2023-04-25 CN disclosed
EP-4142721-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS Bioage Labs, Inc. (US) 2023-03-08 EP disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS INC (US) 2022-06-16 US disclosed
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS BioAge Labs, Inc. 2021-11-18 US disclosed
US-20110110961-A1 PROLYL HYDROXYLASE INHIBITORS AERPIO THERAPEUTICS LLC 2011-05-12 US disclosed
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2007-11-22 US disclosed
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-10-20 US disclosed
US-6930117-B2 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY (US) 2005-08-16 US disclosed
US-20040097560-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones THE PROCTER & GAMBLE COMPANY 2004-05-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150157617-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885LTA4H 2272/4885
US-20210353612-A1 HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE INHIBITORS FOR TREATING AGING-RELATED CONDITIONS HIF1AN, HIF1A, P4HA1 VEGFA 384/4885EGLN1 11/4885LTA4H 592/4885
US-20040097560-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, CYP51A1, CD4 VEGFA 3112/4885EGLN1 926/4885LTA4H 205/4885
US-20070270407-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, IFNG, CD4 VEGFA 2758/4885EGLN1 1060/4885LTA4H 203/4885
US-20220185778-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885LTA4H 550/4885
US-20050234045-A1 N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones IL17A, IFNG, CD4 VEGFA 3064/4885EGLN1 1182/4885LTA4H 177/4885
US-20110111058-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885LTA4H 2272/4885
US-20140364419-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885LTA4H 2272/4885
US-20130158010-A1 METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA HIF1A, HIF1AN, EGLN3 VEGFA 20/4885EGLN1 8/4885LTA4H 2272/4885
US-20110110961-A1 PROLYL HYDROXYLASE INHIBITORS HIF1AN, HIF1A, EGLN2 VEGFA 551/4885EGLN1 5/4885LTA4H 550/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.