Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.77 |
| ▸ | ESRRG | P62508 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.77 |
| ▸ | HPGD | P15428 | 2/20 | 0.77 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.77 |
| ▸ | TP53 | P04637 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | CASP1 | P29466 | 1/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.77 |
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 5/20 | 0.62 |
| ▸ | GFER | P55789 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1131315 | 0.87 | MAPT (1.00) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL1131313 | 0.87 | MAPT (1.00) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL1129782 | 0.87 | MAPT (1.00) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL15315413 | 0.86 | MAPT (0.79) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL15315410 | 0.86 | ESRRG (1.00) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL2536737 | 0.84 | MAPT (0.76) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL8243886 | 0.84 | MAPT (0.76) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL12443591 | 0.84 | ESRRG (0.77) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL8771803 | 0.82 | ESRRG (0.74) | MAPTALDH1A1KDM4EKMT2AESRRG | |
| SCHEMBL12793798 | 0.77 | ALDH1A1 (0.75) | MAPTALDH1A1KDM4EKMT2AESRRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130274233-A1 | MODULATORS OF HEDGEHOG SIGNALING PATHWAY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274233-A1 | MODULATORS OF HEDGEHOG SIGNALING PATHWAY | GLI1, SMO, SHH | MAPT 2947/4885ALDH1A1 3537/4885KDM4E 3038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.