Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15107116 | 1.00 | HTT (0.49) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10078806 | 0.90 | SMN1; SMN2 (0.50) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL10058223 | 0.90 | SMN1; SMN2 (0.50) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL15107844 | 0.84 | SMN1; SMN2 (0.51) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL13779754 | 0.84 | SMN1; SMN2 (0.51) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3671572 | 0.83 | SMN1; SMN2 (0.52) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3671569 | 0.83 | SMN1; SMN2 (0.52) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL951538 | 0.79 | KMT2A (0.59) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL3666535 | 0.79 | KMT2A (0.52) | HTTSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL14497215 | 0.79 | SMN1; SMN2 (0.61) | HTTSMN1; SMN2NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, XDH | HTT 4851/4885SMN1; SMN2 3308/4885NPC1 2510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.