Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | WNT3 | P56703 | 1/20 | 0.46 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671572 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL10058223 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL10078806 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL15316308 | 0.83 | HTT (0.49) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL15107116 | 0.83 | HTT (0.49) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL28816407 | 0.82 | STS (0.44) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL27996466 | 0.82 | STS (0.44) | SMN1; SMN2NPC1RAB9AHTTMEN1 | |
| SCHEMBL13779772 | 0.82 | EPHX1 (0.42) | SMN1; SMN2MEN1KMT2AMAPTWNT3 | |
| SCHEMBL12890921 | 0.81 | KLK7 (0.49) | PARP1 | |
| SCHEMBL951538 | 0.81 | KMT2A (0.59) | SMN1; SMN2NPC1RAB9AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2666774-B1 | Beta-lactamase Inhibitors | MERCK SHARP & DOHME (US) | 2015-01-07 | — | — | EP | disclosed |
| EP-2666774-B1 | Beta-lactamase Inhibitors | MERCK SHARP & DOHME (US) | 2015-01-07 | — | — | EP | disclosed |
| CN-101918407-B | Beta-lactamase inhibitors | MERCK SHARP & DOHME | 2014-02-26 | — | — | CN | disclosed |
| EP-2666774-A1 | Beta-lactamase Inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-11-27 | — | — | EP | disclosed |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-17 | — | — | US | disclosed |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-17 | — | — | US | disclosed |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-10-17 | — | — | US | disclosed |
| EP-2231667-B1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME (US) | 2013-09-04 | — | — | EP | disclosed |
| US-8487093-B2 | β-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8487093-B2 | β-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-8487093-B2 | β-lactamase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-07-16 | — | — | US | disclosed |
| US-20120053350-A1 | PREPARATION OF ALKYL ESTERS OF N-PROTECTED OXO-AZACYCLOALKYLCARBOXYLIC ACIDS | MERCK SHARP & DOHME CORP. | 2012-03-01 | — | — | US | disclosed |
| US-20120053350-A1 | PREPARATION OF ALKYL ESTERS OF N-PROTECTED OXO-AZACYCLOALKYLCARBOXYLIC ACIDS | MERCK SHARP & DOHME CORP. | 2012-03-01 | — | — | US | disclosed |
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-12-01 | — | — | US | disclosed |
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-12-01 | — | — | US | disclosed |
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-12-01 | — | — | US | disclosed |
| CN-101918407-A | Beta-lactamase inhibitors | MERCK & CO INC | 2010-12-15 | — | — | CN | disclosed |
| EP-2231667-A2 | BETA-LACTAMASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009091856-A2 | BETA-LACTAMASE INHIBITORS | MERCK & CO., INC. (US) | 2009-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294777-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, LBR | SMN1; SMN2 3056/4885NPC1 2474/4885RAB9A 972/4885 |
| US-20120053350-A1 | PREPARATION OF ALKYL ESTERS OF N-PROTECTED OXO-AZACYCLOALKYLCARBOXYLIC ACIDS | SULT1A1, SULT1E1, PGD | SMN1; SMN2 3145/4885NPC1 3829/4885RAB9A 3451/4885 |
| US-20130274475-A1 | BETA-LACTAMASE INHIBITORS | MGAM, RPIA, XDH | SMN1; SMN2 3308/4885NPC1 2510/4885RAB9A 770/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.