Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11302875 | 0.83 | NPC1 (0.51) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL9250225 | 0.80 | NPC1 (0.58) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL6379829 | 0.80 | NPC1 (0.55) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL6830087 | 0.80 | NPC1 (0.58) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL23681183 | 0.79 | NPC1 (0.54) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL11745725 | 0.74 | TDP1 (0.45) | MAPTALDH1A1HPGDLMNAKMT2A | |
| SCHEMBL1433300 | 0.74 | NPC1 (0.60) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL1531760 | 0.73 | KDM4E (0.58) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL7757826 | 0.73 | NPC1 (0.58) | MAPTNPC1ALDH1A1HPGDRAB9A | |
| SCHEMBL422787 | 0.73 | RAB9A (0.62) | MAPTNPC1ALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011028651-A1 | INHIBITORS OF HUMAN 15-LIPOXYGENASE-1 | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-03-10 | — | — | WO | disclosed |