Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 11/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15372706 | 0.83 | L3MBTL3 (0.79) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL19127245 | 0.80 | L3MBTL3 (0.43) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL10195702 | 0.79 | L3MBTL3 (0.87) | L3MBTL3L3MBTL1HDAC4MEN1KMT2A | |
| SCHEMBL25498559 | 0.79 | L3MBTL3 (0.87) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL19126810 | 0.78 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL19127153 | 0.78 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL19126808 | 0.78 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL17271879 | 0.77 | L3MBTL3 (0.84) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL3399465 | 0.77 | L3MBTL3 (0.84) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL26773746 | 0.77 | L3MBTL3 (0.84) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655357-B1 | INDAZOLYL TRIAZOLE DERIVATIVES AS IRAK INHIBITORS | MERCK SERONO SA (CH) | 2016-06-22 | — | — | EP | disclosed |
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-9073892-B2 | Indazolyl triazol derivatives | MERCK SERONO S.A. (CH) | 2015-07-07 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | MERCK SERONO S.A. - INTELLECTUAL PROPERTY (CH) | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274241-A1 | INDAZOLYL TRIAZOL DERIVATIVES | NFATC1, IL5, CD4 | L3MBTL3 4428/4885L3MBTL1 4489/4885HDAC4 427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.