Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 10/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19126810 | 1.00 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1HDAC4GRM5MBTD1 | |
| SCHEMBL19127153 | 1.00 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1HDAC4GRM5MBTD1 | |
| SCHEMBL19144644 | 0.86 | L3MBTL3 (0.46) | L3MBTL3L3MBTL1HDAC4GRM5MBTD1 | |
| SCHEMBL15317795 | 0.78 | L3MBTL3 (0.71) | L3MBTL3L3MBTL1HDAC4MBTD1TP53BP1 | |
| SCHEMBL15312577 | 0.78 | GRM3 (0.55) | L3MBTL3L3MBTL1GRM3 | |
| SCHEMBL19127245 | 0.76 | L3MBTL3 (0.43) | L3MBTL3L3MBTL1MBTD1TP53BP1L3MBTL4 | |
| SCHEMBL10195732 | 0.76 | KMT2A (0.62) | L3MBTL3HDAC4GRM5GRM3 | |
| SCHEMBL19967770 | 0.76 | MGLL (0.62) | — | |
| SCHEMBL1447833 | 0.76 | MGLL (0.55) | L3MBTL3L3MBTL1HDAC4GRM5MBTD1 | |
| SCHEMBL968218 | 0.76 | L3MBTL3 (0.59) | L3MBTL3L3MBTL1HDAC4GRM5PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11939314-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2024-03-26 | — | — | US | disclosed |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-11174241-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| CN-108473485-B | Quinolin-2-one derivatives | 默克专利股份公司 | 2021-11-02 | — | — | CN | disclosed |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-10669251-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
| EP-3402792-A1 | QUINOLIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-11-21 | — | — | EP | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174241-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
| US-11939314-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
| US-10669251-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
| US-11186562-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | L3MBTL3 1827/4885L3MBTL1 2500/4885HDAC4 1661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.