Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7705052 | 0.94 | CYP1A2 (0.43) | SIGMAR1IDO1LMNATAAR1MAPT | |
| SCHEMBL79754 | 0.83 | CALM1 (0.50) | IDO1LMNAMAPTCYP3A4KDM4E | |
| SCHEMBL1532140 | 0.82 | TACR1 (0.33) | SIGMAR1IDO1TAAR1MEN1KMT2A | |
| SCHEMBL1531987 | 0.80 | IDO1 (0.37) | IDO1LMNATAAR1MAPTMEN1 | |
| SCHEMBL4390802 | 0.80 | APP (0.37) | IDO1CYP3A4 | |
| SCHEMBL8791282 | 0.80 | ESR1 (0.50) | SIGMAR1IDO1LMNATAAR1MAPT | |
| SCHEMBL8939729 | 0.80 | TAAR1 (0.43) | IDO1LMNATAAR1MEN1KMT2A | |
| SCHEMBL6353303 | 0.80 | IDO1 (0.37) | IDO1LMNATAAR1MAPTMEN1 | |
| SCHEMBL17956849 | 0.80 | CYP3A4 (0.50) | SIGMAR1LMNAMAPTCYP3A4ALDH1A1 | |
| SCHEMBL28044480 | 0.80 | TSHR (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106187858-A | A kind of synthetic method of β iodine N alkoxyamine compounds | 浙江工业大学 | 2016-12-07 | — | — | CN | claimed |
| CN-106543065-B | A kind of 4- trifluoromethyl -2,4- bis- replaces -2,5- dihydro pyrrole derivates and its preparation method and application | 华东师范大学 | 2019-06-11 | — | — | CN | disclosed |
| CN-106543065-A | 2,4 2 replacement of a kind of 4 trifluoromethyl, 2,5 dihydro pyrrole derivates and its preparation method and application | 华东师范大学 | 2017-03-29 | — | — | CN | disclosed |
| CN-106187858-A | A kind of synthetic method of β iodine N alkoxyamine compounds | 浙江工业大学 | 2016-12-07 | — | — | CN | disclosed |
| CN-101522657-B | STAT3/5 activation inhibitor | OTSUKA PHARMACEUTICAL CO.,LTD. (JP) | 2014-10-15 | — | — | CN | disclosed |
| EP-1957073-B1 | MEDICINAL DRUG | OTSUKA PHARMA CO LTD (JP) | 2014-04-23 | — | — | EP | disclosed |
| EP-2612858-A1 | STAT3/5 activation inhibitor | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-07-10 | — | — | EP | disclosed |
| CN-1993339-B | Aromatic compound | OTSUKA PHARMA CO LTD | 2013-05-22 | — | — | CN | disclosed |
| US-20120322807-A1 | STAT3/5 ACTIVATION INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-12-20 | — | — | US | disclosed |
| US-20120238750-A1 | AROMATIC COMPOUND | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-09-20 | — | — | US | disclosed |
| EP-1773797-A2 | AROMATIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006014012-A2 | AROMATIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-02-09 | — | — | WO | disclosed |
| US-5948786-A | BLOCKING TUMOR NECROSIS FACTOR | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-09-07 | — | — | US | disclosed |
| US-4567268-A | Process for preparation of certain tetrahydrofuro[3,4-b]pyridines | MERCK & CO., INC. (US) | 1986-01-28 | — | — | US | disclosed |
| EP-0007347-B1 | ALKYLENGLYCOL COMPOUNDS FOR LOWERING THE LIPID CONTENT AND PROCESSES FOR THE PREPARATION THEREOF | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1981-12-30 | — | — | EP | disclosed |
| US-4275068-A | (BENZYLPHENOXY)-ALKANOLS AS ANTICHOLESTEROL AND ANTILIPEMIC AGENTS | SIEGFRIED AG (CH) | 1981-06-23 | — | — | US | disclosed |
| EP-0007347-A1 | Alkylenglycol compounds for lowering the lipid content and processes for the preparation thereof. | SIEGFRIED AG (CH) | 1980-02-06 | — | — | EP | disclosed |
| US-4182902-A | P-(P'-CHLOROBENZYL) PHENOXYACETIC ACID | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1980-01-08 | — | — | US | disclosed |
| US-4153803-A | Cholesterol-lowering phenoxyalkanoic acid esters | SIEGFRIED AKTIENGESELLSCHAFT (CH) | 1979-05-08 | — | — | US | disclosed |
| WO-1979000116-A1 | NEW GLYCOL COMPOUNDS FOR LOWERING THE LIPID CONTENT | SIEGFRIED AG (CH) | 1979-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238750-A1 | AROMATIC COMPOUND | CBR1, CBR3, CYP1A1 | SIGMAR1 52/4885IDO1 247/4885LMNA 2721/4885 |
| US-20120322807-A1 | STAT3/5 ACTIVATION INHIBITOR | STAT3, JAK2, STAT1 | SIGMAR1 549/4885IDO1 1514/4885LMNA 4742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.