Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | TYR | P14679 | 2/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.42 |
| ▸ | PTGFR | P43088 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8030461 | 0.85 | SLC6A2 (0.48) | IDO1HDAC1HDAC8SLC6A2SLC6A4 | |
| SCHEMBL267012 | 0.82 | SLC6A2 (0.56) | IDO1HDAC1HDAC8SLC6A2SLC6A4 | |
| SCHEMBL16534653 | 0.81 | IDO1 (0.47) | IDO1HDAC1HDAC8SLC6A2SLC6A4 | |
| SCHEMBL2426168 | 0.81 | IDO1 (0.47) | IDO1HDAC1HDAC8SLC6A2SLC6A4 | |
| SCHEMBL19481151 | 0.81 | IDO1 (0.43) | IDO1HDAC1HDAC8SLC6A2SLC6A4 | |
| SCHEMBL8418978 | 0.78 | IDO1 (0.41) | IDO1HDAC1HDAC8POLQPTGFR | |
| SCHEMBL17329111 | 0.78 | IDO1 (0.59) | IDO1HDAC1HDAC8SLC6A2SLC6A4 | |
| SCHEMBL7401230 | 0.77 | PPARG (0.47) | IDO1HDAC1HDAC8PTGFRGAA | |
| SCHEMBL16269252 | 0.76 | ALDH1A1 (0.48) | IDO1ALDH1A1 | |
| SCHEMBL21576141 | 0.76 | POLQ (0.47) | IDO1HDAC1HDAC8SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834233-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | Orion Corporation (FI) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013150173-A1 | NEW ALPHA2 ADRENOCEPTOR AGONISTS | ORION CORPORATION (FI) | 2013-10-10 | — | — | WO | disclosed |