Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320939 | 0.92 | AR (0.33) | ARGPR35VCAM1 | |
| SCHEMBL23832201 | 0.86 | TTR (0.37) | TTRALBVCAM1RAF1ALDH1A1 | |
| SCHEMBL15321415 | 0.81 | AR (0.37) | ARCRHR1GPR35TTRALB | |
| SCHEMBL15321536 | 0.78 | EGLN2 (0.36) | TTRALBRAF1ALDH1A1CYP2A6 | |
| SCHEMBL7895709 | 0.77 | HPGD (0.36) | ARGPR35TTRALB | |
| SCHEMBL7895710 | 0.77 | HPGD (0.36) | ARGPR35TTRALB | |
| SCHEMBL1145042 | 0.75 | AR (0.44) | ARTTRALBVCAM1ALDH1A1 | |
| SCHEMBL13696502 | 0.74 | AR (0.42) | ARCRHR1GPR35TTRALB | |
| SCHEMBL183056 | 0.74 | RAPGEF4 (0.44) | ALDH1A1 | |
| SCHEMBL29421109 | 0.74 | RAPGEF4 (0.44) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013149996-A9 | SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS | ALMIRALL, S.A. (ES) | 2014-02-20 | — | — | WO | disclosed |
| WO-2013149996-A1 | SUBSTITUTED TRICYCLIC COMPOUNDS WITH ACTIVITY TOWARDS EP1 RECEPTORS | ALMIRALL, S.A. (ES) | 2013-10-10 | — | — | WO | disclosed |