Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | SCN4A | P35499 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Proline SCHEMBL21747582 | 0.88 | MEN1 (0.47) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL21220103 | 0.88 | MEN1 (0.47) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL2228246 | 0.88 | MEN1 (0.47) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL29811219 | 0.88 | MEN1 (0.47) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL2228243 | 0.88 | MEN1 (0.47) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL28049461 | 0.86 | MEN1 (0.48) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL718906 | 0.85 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| D-Proline SCHEMBL21462052 | 0.85 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL462226 | 0.85 | BLM (0.52) | MEN1BLMKMT2ADPP4DPP8 | |
| Proline SCHEMBL2939 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104619196-A | Novel flavour compositions with improved flavour and/or flavour shelf-life | NESTEC SA | 2015-05-13 | — | — | CN | disclosed |