Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.31 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16289797 | 0.72 | — | — | |
| SCHEMBL1977973 | 0.70 | FFAR1 (0.43) | GRM5CYP1A2CHRNB2CHRNA2CHRNB4 | |
| SCHEMBL1033476 | 0.69 | — | — | |
| SCHEMBL129622 | 0.69 | — | — | |
| SCHEMBL1032627 | 0.67 | — | — | |
| SCHEMBL1202438 | 0.67 | GRM5 (0.45) | GRM5CYP1A2 | |
| SCHEMBL16685697 | 0.67 | GRM5 (0.45) | GRM5CYP1A2CHRNB2CHRNA2CHRNB4 | |
| SCHEMBL15324177 | 0.67 | GRM5 (0.45) | GRM5CYP1A2CHRNB2CHRNA2CHRNB4 | |
| SCHEMBL2502685 | 0.63 | KDM4E (0.41) | CYP1A2CHRNB2CHRNA2CHRNB4CHRNA3 | |
| SCHEMBL4807933 | 0.63 | GRM5 (0.96) | GRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | claimed |
| WO-2013153535-A1 | TRICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |