⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901941 | 0.92 | — | — | |
| SCHEMBL22072994 | 0.90 | KDM4E (0.35) | — | |
| SCHEMBL22073002 | 0.90 | KDM4E (0.32) | — | |
| SCHEMBL22073010 | 0.88 | KDM4E (0.37) | — | |
| SCHEMBL2974735 | 0.84 | KMT2A (0.33) | — | |
| SCHEMBL19121643 | 0.80 | — | — | |
| SCHEMBL2968855 | 0.78 | L3MBTL3 (0.41) | — | |
| SCHEMBL737934 | 0.76 | — | — | |
| SCHEMBL27676503 | 0.75 | POLB (0.32) | — | |
| SCHEMBL26421197 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3815685-A2 | COMPOUND COMPRISING A MAO TARGETING/SEEKER MOIETY FOR TREATING HUMAN GLIOMAS | The Methodist Hospital Research Institute (US) | 2021-05-05 | — | — | EP | claimed |
| US-10555936-B2 | Chemotherapeutic compositions and methods for treating human gliomas | THE METHODIST HOSPITAL (US) | 2020-02-11 | — | — | US | claimed |
| CN-104136026-B | Human glioma comprising MAO targetings/seeker part, which treats, uses compound | 卫理公会医院研究所 | 2018-03-02 | — | — | CN | claimed |
| EP-2804604-A1 | COMPOUND COMPRISING A MAO TARGETING/ SEEKER MOIETY FOR TREATING HUMAN GLIOMAS | The Methodist Hospital Research Institute (US) | 2014-11-26 | — | — | EP | claimed |
| CN-104136026-A | Compound comprising a mao targeting/ seeker moiety for treating human gliomas | METHODIST HOSPITAL RES INST | 2014-11-05 | — | — | CN | claimed |
| US-20140323513-A1 | Chemotherapeutic Compositions and Methods for Treating Human Gliomas | THE METHODIST HOSPITAL | 2014-10-30 | — | — | US | claimed |
| WO-2013151584-A1 | COMPOUND COMPRISING A MAO TARGETING/ SEEKER MOIETY FOR TREATING HUMAN GLIOMAS | THE METHODIST HOSPITAL RESEARCH INSTITUTE (US) | 2013-10-10 | — | — | WO | claimed |
| EP-3815685-A2 | COMPOUND COMPRISING A MAO TARGETING/SEEKER MOIETY FOR TREATING HUMAN GLIOMAS | The Methodist Hospital Research Institute (US) | 2021-05-05 | — | — | EP | disclosed |
| US-10555936-B2 | Chemotherapeutic compositions and methods for treating human gliomas | THE METHODIST HOSPITAL (US) | 2020-02-11 | — | — | US | disclosed |
| CN-104136026-B | Human glioma comprising MAO targetings/seeker part, which treats, uses compound | 卫理公会医院研究所 | 2018-03-02 | — | — | CN | disclosed |
| CN-104136026-A | Compound comprising a mao targeting/ seeker moiety for treating human gliomas | METHODIST HOSPITAL RES INST | 2014-11-05 | — | — | CN | disclosed |