Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESPL1 | Q14674 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15324862 | 0.86 | ESPL1 (0.38) | ESPL1LMNAALDH1A1HIF1AMAPT | |
| SCHEMBL14995344 | 0.81 | LRRK2 (0.40) | PDE3BPDE3ALMNAALDH1A1MAPT | |
| SCHEMBL14995266 | 0.79 | LRRK2 (0.45) | PDE3BPDE3ALMNAALDH1A1MAPT | |
| SCHEMBL25386082 | 0.78 | MAPT (0.41) | PDE3BPDE3ALMNAALDH1A1MAPT | |
| SCHEMBL25387050 | 0.77 | MAPT (0.47) | PDE3BPDE3ALMNAALDH1A1MAPT | |
| SCHEMBL1654900 | 0.76 | PDE3B (0.48) | ESPL1PDE3BPDE3ALMNAALDH1A1 | |
| SCHEMBL23578236 | 0.75 | SIRT6 (0.41) | PDE3BPDE3ALMNAALDH1A1MAPT | |
| SCHEMBL15323771 | 0.74 | CHRM5 (0.44) | ALDH1A1MAPTTDP1NPSR1 | |
| SCHEMBL23011952 | 0.73 | SYK (0.40) | PDE3BPDE3ALMNAALDH1A1KRAS | |
| SCHEMBL9971075 | 0.73 | MAPT (0.37) | ESPL1LMNAALDH1A1MAPTCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013153539-A1 | TRICYCLIC COMPOUNDS AS TEC KINASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-10-17 | — | — | WO | disclosed |