Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1GSK3AGSK3BHRH1HRH2HTR7IDH1IDH2IMPA1IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BBOX1 | O75936 | 7/20 | 0.33 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.30 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL119895 | 0.95 | LMNA (0.43) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL29356844 | 0.93 | LMNA (0.41) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15323416 | 0.93 | LMNA (0.41) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15323746 | 0.92 | MEN1 (0.40) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15323411 | 0.92 | MEN1 (0.40) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15323531 | 0.90 | MEN1 (0.39) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15324015 | 0.90 | MEN1 (0.39) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL2345397 | 0.90 | CA4 (0.52) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL2345393 | 0.89 | CA4 (0.50) | LMNAMEN1KMT2ACYP3A4SLC5A7 | |
| Citric Acid SCHEMBL15322509 | 0.89 | MEN1 (0.38) | LMNAMEN1KMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |