Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 18/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3108925 | 0.99 | SLC6A9 (0.55) | SLC6A9KCNH2HRH3LTA4H | |
| SCHEMBL15323634 | 0.98 | SLC6A9 (0.53) | SLC6A9KCNH2HRH3LTA4H | |
| Hydrochloric Acid SCHEMBL3099051 | 0.97 | SLC6A9 (0.53) | SLC6A9KCNH2HRH3LTA4H | |
| SCHEMBL3105653 | 0.89 | SLC6A9 (0.67) | SLC6A9KCNH2 | |
| SCHEMBL3109107 | 0.89 | SLC6A9 (0.56) | SLC6A9KCNH2 | |
| Hydrochloric Acid SCHEMBL3108660 | 0.88 | SLC6A9 (0.66) | SLC6A9KCNH2 | |
| SCHEMBL3099729 | 0.87 | SLC6A9 (0.53) | SLC6A9KCNH2 | |
| SCHEMBL3714071 | 0.86 | SIGMAR1 (0.52) | SLC6A9KCNH2 | |
| SCHEMBL15324310 | 0.86 | SLC6A9 (0.51) | SLC6A9KCNH2 | |
| SCHEMBL3094440 | 0.86 | SLC6A9 (0.61) | SLC6A9KCNH2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396296-B1 | AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBVIE DEUTSCHLAND (DE) | 2016-05-25 | — | — | EP | claimed |
| US-9067871-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-30 | — | — | US | claimed |
| US-8563617-B2 | Aminotetraline derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2013-10-22 | — | — | US | claimed |