Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Deaminohydroxyvaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TET2 | Q6N021 | 3/20 | 0.32 |
| ▸ | KDM4A | O75164 | 2/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.32 |
| ▸ | TET3 | O43151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL15323695 | 0.88 | TET2 (0.41) | TET2KDM4AKDM4CKDM2ATET3 | |
| Deaminohydroxyvaline SCHEMBL15322990 | 0.87 | — | — | |
| Deaminohydroxyvaline SCHEMBL15324660 | 0.85 | GPR84 (0.31) | — | |
| Deaminohydroxyvaline SCHEMBL15322556 | 0.83 | TET2 (0.46) | TET2KDM4AKDM4CKDM2ATET3 | |
| Deaminohydroxyvaline SCHEMBL15324291 | 0.81 | GPR84 (0.33) | TET2KDM4AKDM4CKDM2ATET3 | |
| Deaminohydroxyvaline SCHEMBL15323082 | 0.80 | DPP7 (0.31) | — | |
| Deaminohydroxyvaline SCHEMBL15323086 | 0.80 | DPP7 (0.31) | — | |
| Deaminohydroxyvaline SCHEMBL15323274 | 0.75 | DPP7 (0.31) | — | |
| Deaminohydroxyvaline SCHEMBL15324671 | 0.74 | GPR84 (0.40) | TET2KDM4AKDM4CKDM2ATET3 | |
| 3-Hydroxybutyric Acid, (+/-)- SCHEMBL15322333 | 0.74 | SLC22A6 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |