Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 20/20 | 0.59 |
| ▸ | CTSL | P07711 | 18/20 | 0.59 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15327277 | 0.94 | CTSS (0.62) | CTSSCTSLCTSK | |
| SCHEMBL15327313 | 0.90 | CTSS (0.63) | CTSSCTSLCTSK | |
| SCHEMBL694472 | 0.90 | CTSS (0.73) | CTSSCTSLCTSK | |
| SCHEMBL15327407 | 0.89 | CTSS (0.62) | CTSSCTSL | |
| SCHEMBL15327523 | 0.89 | CTSS (0.62) | CTSSCTSL | |
| SCHEMBL15327372 | 0.89 | CTSS (0.61) | CTSSCTSLCTSK | |
| SCHEMBL15327395 | 0.88 | CTSS (0.60) | CTSSCTSLCTSK | |
| SCHEMBL15327567 | 0.87 | CTSL (0.60) | CTSSCTSLCTSK | |
| SCHEMBL15327413 | 0.87 | CTSS (0.52) | CTSSCTSL | |
| SCHEMBL15327549 | 0.87 | CTSL (0.63) | CTSSCTSLCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-B1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | HOFFMANN LA ROCHE (CH) | 2013-10-23 | — | — | EP | claimed |