Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.82 |
| ▸ | KDR | P35968 | 5/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | CASP3 | P42574 | 1/20 | 0.66 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.66 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.66 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30061443 | 1.00 | TDP1 (1.00) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL29647754 | 0.90 | HDAC6 (1.00) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL19631488 | 0.90 | HDAC6 (1.00) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL15270551 | 0.87 | HDAC6 (0.79) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL6260903 | 0.87 | KDR (1.00) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL29434873 | 0.87 | KDR (1.00) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL28462225 | 0.86 | TDP1 (0.76) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL29510045 | 0.86 | TDP1 (0.76) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL16456332 | 0.86 | HDAC6 (0.77) | TDP1HDAC6KDRL3MBTL1GAA | |
| SCHEMBL17552183 | 0.86 | HDAC6 (0.77) | TDP1HDAC6KDRL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113336784-B | 3-substituted benzofluorenone or 3-substituted naphthofluorenone derivatives and synthesis method thereof | 上海大学 | 2022-11-18 | — | — | CN | disclosed |
| CN-111690947-B | Electrochemical synthesis method of trifluoromethylated aryl amide derivative | 浙江工业大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-113336784-A | 3-substituted benzofluorenone or 3-substituted naphthofluorenone derivatives and synthesis method thereof | 上海大学 | 2021-09-03 | — | — | CN | disclosed |
| CN-111423372-B | Method for preparing N- (5-hydroxyquinoline-8-yl) benzamide compound by electrochemical microchannel reaction device | 南京工业大学 | 2021-04-27 | — | — | CN | disclosed |
| CN-111690947-A | Electrochemical synthesis method of trifluoromethylated aryl amide derivative | 浙江工业大学 | 2020-09-22 | — | — | CN | disclosed |
| CN-109320497-B | Method for preparing phenanthridinone compound by copper compound induction | 广州大学 | 2020-07-31 | — | — | CN | disclosed |
| CN-111423372-A | Method for preparing N- (5-hydroxyquinoline-8-yl) benzamide compound by electrochemical microchannel reaction device | 南京工业大学 | 2020-07-17 | — | — | CN | disclosed |
| CN-109320497-A | A method of phenanthridines ketone compounds are prepared by copper compound induction | 广州大学 | 2019-02-12 | — | — | CN | disclosed |
| US-9108936-B2 | Substituted 4-aminobenzamides as KCNQ2/3 modulators | GRUENENTHAL GMBH (DE) | 2015-08-18 | — | — | US | disclosed |
| EP-2844645-A1 | SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2015-03-11 | — | — | EP | disclosed |
| WO-2013156155-A1 | SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS | Grünenthal GmbH (DE) | 2013-10-24 | — | — | WO | disclosed |
| US-20130281452-A1 | SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS | GRUENENTHAL GMBH (DE) | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281452-A1 | SUBSTITUTED 4-AMINOBENZAMIDES AS KCNQ2/3 MODULATORS | KCNJ2, KCNQ2, KCNQ1 | TDP1 3737/4885HDAC6 1515/4885KDR 3252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.